On August 27, 2006, Ortiz tied his career high in home runs by hitting his 47th home run of the year off Cha Seung Baek of the Seattle Mariners. On September 20, 2006, Ortiz tied Jimmie Foxx's single season Red Sox home run record of 50 set in 1938; in the 6th inning against Minnesota Twins starting pitcher Boof Bonser, Big Papi launched the ball into the center field bleachers behind the Red Sox bullpen. Ortiz has the unique achievement of having increased his season home run tally in each of seven consecutive seasons (starting from 1999, year-by-year he has hit 0, 10, 18, 20, 31, 41, 47 and 54 HRs).
On September 21, 2006, Ortiz broke Jimmie Foxx's single season Red Sox home run record by hitting his 51st home run off his former teammate, Johan Santana of the Minnesota Twins. The longball came on a 1-0 pitch in the first inning and it was his 44th home run as a designated hitter in 2006, breaking his own American League single-season record. Ortiz then hit his 52nd home run off reliever Matt Guerrier on a full count in the seventh inning. He finished the season with a franchise record 54 home runsIn 2007, Ortiz once again was a major force as he helped lead the Boston Red Sox to their seventh World Series title. Despite playing the entire season with a torn meniscus in his right knee as well as nagging injuries to his shoulder and quadriceps, he finished the year hitting .332 with 35 home runs and 117 RBI. In addition, he hit 52 doubles, led the American League in extra base hits and had an OPS of 1.066. In the postseason Ortiz batted .370 with 3 home runs and 10 RBI.